| 货号 | 13365-1ea |
| 描述 | Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many cancer samples.1,2 Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis.2,3 The known isoforms of PDCD4 differ only at the N-termini with isoform 1 comprised of 468 amino acids and isoform 2 comprised of 458 amino acids. Each isoform contains two MA-3 domains essential for PDCD4 binding eIF4A and thereby suppression of cell cycle regulation and growth factor production.3,2,4 This antibody is capable of detecting both PDCD4 isoforms. Additional protein modifications are possible and can explain the range of masses detected by the immunoblotting (52-64 kDa).1 The molecular mechanisms of PDCD4 influence on tumor suppression are becoming known but warrant further research.3,5,2 |
| 别名 | PDCD4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cmarik, J.L.,Min, H.,Hegamyer, G., et al. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proceedings of the National Academy of Sciences of the United States of America 96(24), 14037-14042 (1999). 2.Nieves-Alicea, R.,Colburn, N.H.,Simeone, A.M., et al. Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression. Breast Cancer Research and Treatment (2008). 3.Bitomsky, N.,Wethkamp, N.,Marikkannu, R., et al. siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression. Oncogene (2008). 4.Yang, H.S.,Cho, M.H.,Zakowicz, H., et al. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Molecular and Cellular Biology 24(9), 3894-3906 (2004). 5.Böhm, M.,Sawicka, K.,Siebrasse, J.P., et al. The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene 22, 4905-4910 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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