| 货号 | 13079-1ea |
| 描述 | ApoA1 is a major protein component in high-density lipoproteins (HDLs). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues and transports cholesterol to the liver and other tissues for excretion and steroidogenesis.1 Serum ApoA1 levels are inversely related to the risk of developing atherosclerosis.2 Loss-of-function mutations are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis.3,4 ApoA1 is comprised of a single polypeptide chain of 243 amino acids residues with an estimated molecular weight of 28 kDa. Cayman’s ApoA1 Polyclonal Antibody (Item No. 10008463) detects the protein by western blot analysis in tissue/cell samples such as liver, intestine, and HepG2 cells. |
| 别名 | Apolipoprotein A1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ajees, A.A.,Anantharamaiah, G.M.,Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proceedings of the National Academy of Sciences of the United States of America 103(7), 2126-2131 (2006). 2.Haas, M.J.,Reinacher, D.,Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. Journal of Molecular Endocrinology 27, 43-57 (2001). 3.Tall, A.R. and Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. Journal of Clinical Investigation 106(10), 1205-1207 (2000). 4.Cheung, M.C.,Mendez, A.J.,Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. Journal of Clinical Investigation 91, 522-529 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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