| 货号 | 10326-1ea |
| 描述 | Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages.1 This receptor is also expressed in brain, liver, lung, and kidney tissues.1,2 Chemerin (TIG2) has been identified as the natural ligand for this receptor.3 Resolvin E1 has also been identified as a ligand for CMKLR1; acting to dampen cellular responses to inflammation.1,4,5 Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine.2,6,7 Human CMKLR1 shares 80% sequence homology with its murine ortholog.3 The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman’s CMKLR1 polyclonal antibody recognizes the C-terminal region of the protein and cell permeabilization is recommended prior to whole cell staining. |
| 别名 | CMKLR1;DEZ;GPCR ChemR23;Resolvin E1 Receptor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arita, M.,Bianchini, F.,Aliberti, J., et al. Sterochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. Journal of Experimental Medicine 201(5), 713-722 (2005). 2.Takahashi, M.,Takahashi, Y.,Takahashi, K., et al. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Letters 582, 573-578 (2008). 3.Wittamer, V.,Grégoire, F.,Robberecht, P., et al. The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. The Journal of Biological Chemisty 279(11), 9956-9962 (2004). 4.Arita, M.,Ohira, T.,Sun, Y.P., et al. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. Journal of Immunology 178, 3912-3917 (2007). 5.Cash, J.L.,Hart, R.,Russ, A., et al. Synthetic chemerin-derived peptides suppress inflammation through ChemR23. Journal of Environmental Monitoring 205(4), 767-775 (2008). 6.Roh, S.G.,Song, S.H.,Choi, K.C., et al. Chemerin-a new adipokine that modulates adipogenesis via its own receptor. Biochemical and Biophysical Research Communications 362, 1013-1018 (2007). 7.Campbell, E.L.,Louis, N.A.,Tomassetti, S.E., et al. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. The FASEB Journal 21, 3162-3170 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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