NAPE-PLD Blocking Peptide (aa 6-20)
货号：
10304-1ea 基本售价：
1498.0 元 规格：
200 ug
产品信息
概述| 货号 | 10304-1ea |
| 描述 | To be used in conjunction with Cayman’s NAPE-PLD polyclonal antibody (aa 6-20) (Item No. 10306) to block protein-antibody complex formation during analysis of NAPE-PLD · N-acylethanolamines (NAEs) are involved in diverse biological processes such as inflammatory regulation, apoptosis, and tissue degeneration.1 In animals, NAEs are mainly biosynthesized via a membrane phospholipid-dependent pathway, which is the enzymatic hydrolysis of N-acyl-phosphatidylethanolamine (NAPE). The enzyme catalyzing this reaction is a phospholipase D subtype selective for NAPE named N-acylphosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD). It has been cloned from mouse, rat, and human and is 393-396 amino acids in length, with an estimated molecular weight of 46 kDa. Both NAPE-PLD mRNA and protein activity have been detected in a wide range of tissues with the highest levels in brain, kidney, and testis.2 In rat, NAPE-PLD activity in the brain is low in neonates and is 15-fold higher in adults, whereas the activity remains constant in the heart during development.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hansen, H.S.,Moesgaard, B.,Petersen, G., et al. Putative neuroprotective actions of N-acyl-ethanolamines. Pharmacology & Therapeutics 95, 119-126 (2002).
2.Okamoto, Y.,Morishita, J.,Tsuboi, K., et al. Molecular characterization of a phospholipase D generating anandamide and its congeners. The Journal of Biological Chemisty 279(7), 5298-5305 (2004).
3.Moesgaard, B.,Petersen, G.,Jaroszewski, J.W., et al. Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain: A 31P NMR and enzyme activity study. Journal of Lipid Research 41, 985-990 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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