11β-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide
货号：
10242-1ea 基本售价：
1498.0 元 规格：
200 ug
产品信息
概述| 货号 | 10242-1ea |
| 描述 | 11-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.1 Expression of 11β-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney.2 In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation.3 Cayman’s 11β-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells. |
| 别名 | 11β-HSD2; |
| 应用 | WB |
性能| 供应商 | Cayman |
| 应用文献 |
1.Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. Journal of Clinical Endocrinology and Metabolism 88(6), 2384-2392 (2003).
2.White, P.C.,Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocrine Reviews 18(1), 135-156 (1997).
3.Thompson, A.,Han, V.K.M., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. Journal of Steroid Biochemistry and Molecular Biology 88, 367-375 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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