| 货号 | 10225-1ea |
| 描述 | GPR55 is a G protein-coupled receptor that has been identified as a novel cannabinoid receptor, although its exact role is still controversial.1,2 Previously central cannabinoid (CB1) and peripheral cannabinoid (CB2), two widely characterized receptors have been shown to bind THC the active component of cannabis and other endocannabinoids. Mounting evidence suggests that additional receptors play a role in CB-related signal transduction and GPR55 has been identified as one of them.3 This receptor is widely expressed in the brain, specifically found in large dorsal root ganglion neurons.4 Along with binding THC, it also shows high affinity to anandamide, methanandamide, JWH 015, and many other CB ligands.5,6 The human protein shows 75% and 78% overall sequence homology with the rat and murine proteins, respectively.1 GPR55 is composed of 319 amino acids and has an expected molecular weight of 37 kDa. Post-translational modifications such as glycosylation may retard receptor electrophoretic migration and thereby protein signal may be detected above 37 kDa. |
| 别名 | G Protein-Coupled Receptor 55; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ryberg, E.,Larsson, N.,Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. British Journal of Pharmacology 152, 1092-1101 (2007). 2.Baker, D.,Pryce, G.,Davies, W.L., et al. In silico patent searching reveals a new cannabinoid receptor. Trends in Pharamacological Sciences 27(1), 1-4 (2006). 3.Brown, A.J. Novel cannabinoid receptors. British Journal of Pharmacology 152, 567-575 (2007). 4.Lauckner, J.E.,Jensen, J.B.,Chen, H.Y., et al. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proceedings of the National Academy of Sciences of the United States of America 105(7), 2699-2704 (2008). 5.Oka, S.,Nakajima, K.,Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochemical and Biophysical Research Communications 362, 928-934 (2007). 6.Pertwee, R.G. GPR55: A new member of the cannabinoid receptor clan? British Journal of Pharmacology 152, 984-986 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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