Adenosine Receptor A2A Blocking Peptide
货号：
10092-1ea 基本售价：
1498.0 元 规格：
200 ug
产品信息
概述| 货号 | 10092-1ea |
| 描述 | Adenosine Receptor A2A is a multi-pass membrane protein that is normally localized to the plasma membrane.1 This receptor is part of the G-protein coupled receptor family that binds adenosine and keeps it in equilibrium inside and outside the cell. Along with establishing this equilibrium, A2AR serves multiple functions and antagonists of this receptor have been targeted for the treatment of Parkinson’s disease.2,3 This protein is primarily found in the striatum, but can also be found in immune cells and other tissues as well.2A2AR is 412 amino acids long with an expected molecular weight of 45 kDa. The receptor also has multiple glycosylation sites that explain the higher band shift seen in western blotting.1 |
| 别名 | A2AR; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Piersen, C.E.,True, C.D., and Well, J.N. A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. Molecular Pharmacology 45(5), 861-870 (1994).
2.Fredholm, B.B.,Chern, Y.,Franco, R., et al. Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology 83, 263-276 (2007).
3.Ledent, C.,Vaugeois, J.M.,Schiffmann, S.N., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2A receptor. Nature 388, 674-678 (1997).
|
| 免疫原 | human adenosine receptor a2A amino acids 213 – 220 |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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