| 货号 | 5856/50 |
| 别名 | 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9 |
| 供应商 | Tocris |
| 生物活性 | HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 720.94 |
| 分子式 | C37H48N6O5 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol |
| 参考文献 | Zeldinet al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4. PMID: 14657084. Kempfet al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602. PMID: 9484509. Kempfet al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484. PMID: 7708670. |