| 货号 | 5739/1 |
| 别名 | (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Ac |
| 供应商 | Tocris |
| 生物活性 | PKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 390.47 |
| 分子式 | C22H30O6 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Shenet al (2015) The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 356 686. PMID: 25449427. Wanget al (2015) K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 1237. PMID: 26590425. Wanget al (2014) Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. BioMed Res.Int. 2014 968027. PMID: 25136641. |