| 货号 | 5711/50 |
| 别名 | 2-Cyano-1,4-dihydro-6-methyl-4-(3-n |
| 供应商 | Tocris |
| 生物活性 | Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβin vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 385.37 |
| 分子式 | C19H19N3O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Pariset al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927. PMID: 25331948. Choet al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399. PMID: 2552119. |