| 货号 | 5906/100 |
| 别名 | 4-[(4-Methyl-1-piperazinyl)methyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-siscells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 589.71 |
| 分子式 | C29H31N7O.CH |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Juurikiviet al (2005) Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann.Rheum.Dis. 64 1126. PMID: 16014680. Buchdungeret al (1996) Inhibition of the Abl protein-tyrosine kinase in vitroandin vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56 100. PMID: 8548747. |