| 货号 | 4180/1 |
| 别名 | 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3 |
| 供应商 | Tocris |
| 生物活性 | Potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 420.47 |
| 分子式 | C24H29NaO5 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Miyamotoet al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889. PMID: 14504133. Saitoet al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497. PMID: 7609334. |