| 货号 | 5630/5 |
| 别名 | 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[( |
| 供应商 | Tocris |
| 生物活性 | Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 809 |
| 分子式 | C43H64N6O9 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Allenet al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitroandin vivo. Exp.Eye Res. 123 8. PMID: 24768597. Weihofenet al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528. PMID: 12621027. Weihofenet al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951. PMID: 10921927. |