| 货号 | 9950S |
| 供应商 | CST |
| 背景 | Trichostatin A is an antifungal antibiotic derived from Streptomyces that inhibits mammalian histone deacetylases (1,2). When used at nanomolar concentrations, trichostatin A causes the accumulation of acetylated histones in a quite specific and reversible manner (2,3). Trichostatin A has also been shown to inhibit both G1- and G2-phases of the mammalian cell cycle and has been tested for use as a potential anticancer agent (2-5). |
| 存放说明 | -20C |
| 参考文献 | Tsuji, N. et al. (1976) J. Antibiot. 29, 1-6. Yoshida, M. et al. (1990) J. Biol. Chem. 265, 17174-17179. Kijima, M. et al. (1993) J. Biol. Chem. 268, 22429-22435. Ailenberg, M. and Silverman, M. (2002) Biochem. Biophys. Res. Commun. 298, 110-115. Maecker, H. et al. (2002) Cancer Cell 2, 139-148. |
Western blot analysis of extracts from various cell lines, untreated or TSA-treated (400 nM for 12 hours), using Acetyl-Histone H2A (Lys5) Antibody. 使用Acetyl-Histone H2A (Lys5) Antibody，免疫印迹分析不同的细胞系，细胞分为untreated或TSA-treated (400 nM for 12 hours)。 |
