| 货号 | 2191/50 |
| 别名 | S-(Triphenylmethyl)-L-cysteine; NSC 83265 |
| 供应商 | Tocris |
| 生物活性 | Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 363.47 |
| 分子式 | C22H21NO2S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 2799-07-7 |
| 参考文献 | Brieret al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072. PMID: 15476401. DeBoniset al(2004)In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079. PMID: 15367702. |