| 货号 | 2682/100 |
| 别名 | 4-Phenylbutyric acid, sodium salt |
| 供应商 | Tocris |
| 生物活性 | Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγactivation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 186.18 |
| 分子式 | C10H11NaO2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 25 mM in DMSO |
| CAS号 | 1716-12-7 |
| 参考文献 | Khanet al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977. PMID: 21894430. Ammerpohlet al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73. PMID: 17164759. Appelskoget al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419. PMID: 15138583. Engelhardet al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 3797. |