| 货号 | 3848/50 |
| 别名 | 9α,13α,14α-7,8-Didehydro-4-hydroxy-3,7-dimeth |
| 供应商 | Tocris |
| 生物活性 | Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 365.85 |
| 分子式 | C19H23NO4.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 115-53-7 |
| 参考文献 | Desbordeset al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853. Wanget al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209. PMID: 18692550. Qianet al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 423. Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1. PMID: 61710. |