| 货号 | 3708/1 |
| 别名 | scPanx |
| 供应商 | Tocris |
| 生物活性 | Scrambled version of 10Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro.10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1242.37 |
| 分子式 | C58H79N15O16 |
| 可溶性/溶解性 | Soluble to 0.50 mg/ml in water |
| 序列号 | FSVYWAQADR |
| 参考文献 | Thompsonet al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555. PMID: 19056988. Wanget al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112. PMID: 17652431. Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor. EMBO J. 25 5071. PMID: 17036048. |