| 货号 | 1439/100 |
| 别名 | Ammoniated ruthenium oxychloride |
| 供应商 | Tocris |
| 生物活性 | Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 786.35 |
| 分子式 | H42N14O2Ru3Cl6 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| CAS号 | 11103-72-3 |
| 参考文献 | Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 51 159. PMID: 10353985. Xuet al (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274 32680. PMID: 10551824. Amann and Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49 849. PMID: 1715010. Bernardiet al (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23 1645. PMID: 6202317. |