R8-T198wt (1 MG)
货号：
4592/1 基本售价：
1417.7 元 规格：
1 mg
产品信息
性能| 供应商 | Tocris |
| 生物活性 | Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitroandin vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2820.33 |
| 分子式 | C111H211N59O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in 20% acetonitrile / water |
| 序列号 | GGGRRRRRRRRGCKKPGLRRRQT |
| 参考文献 | Morishitaet al (2011) Cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J.Biol.Chem. 286 2681. PMID: 21062737. |
