| 货号 | 2775/100 |
| 别名 | 4,4'-[(1-Methylethylidene)bis(thio)] |
| 供应商 | Tocris |
| 生物活性 | Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 516.84 |
| 分子式 | C31H48O2S2 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 23288-49-5 |
| 参考文献 | Wuet al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477. PMID: 17293560. Ruixinget al (2006) Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549. PMID: 17101546. Kuet al (1990) Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties. FASEB J. 4 1645. PMID: 2318380. |