| 货号 | 2689/50 |
| 别名 | Sodium metatungstate; Sodium polyoxotungstate |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12(Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 2986.01 |
| 分子式 | H2O40Na6W12 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 12141-67-2 |
| 参考文献 | Wallet al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251. PMID: 18768144. Grenzet al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863. PMID: 17442731. Mulleret al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943. PMID: 16997558. |