| 货号 | 3026/50 |
| 别名 | N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1- |
| 供应商 | Tocris |
| 生物活性 | Selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 481.5 |
| 分子式 | C27H23N5O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 103177-37-3 |
| 参考文献 | Suzukiet al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395. PMID: 12870835. Heiseet al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531. PMID: 10851239. Lynchet al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789. PMID: 10391245. |