| 货号 | 1228/10 |
| 别名 | [5-(2-Thienylcarbonyl)-1H-benzimida |
| 供应商 | Tocris |
| 生物活性 | Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (dependingon cell cycle phase) and increases Cas9-mediated gene editing frequencies. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >95 % |
| 计算分子量 | 301.32 |
| 分子式 | C14H11N3O3S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 31430-18-9 |
| 参考文献 | Linet al (2014) Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife 3 e04766. PMID: 25497837. Mizushimaet al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757. Webbet al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591. Vasquezet al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivoandin vitro. Mol.Biol.Cell 8 973. PMID: 9201709. |