| 货号 | 2877/50 |
| 别名 | 3,4-Methylenedioxy-β-nitrostyrene |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 193.16 |
| 分子式 | C9H7NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 1485-00-3 |
| 参考文献 | Wanget al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601. PMID: 17601492. Wanget al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380. PMID: 16837624. |