| 货号 | 4014/50 |
| 别名 | P,P'-(4-Amino-1-hydroxybutylidene)bi |
| 供应商 | Tocris |
| 生物活性 | Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 271.08 |
| 分子式 | C4H12NNaO7P2 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 121268-17-5 |
| 参考文献 | Fournieret al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945. PMID: 18974139. Bergstromet al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231. PMID: 10620343. Fisheret al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96133. |