| 货号 | 3268/50 |
| 别名 | [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethyl |
| 供应商 | Tocris |
| 生物活性 | Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 493.94 |
| 分子式 | C23H27N3O7.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in water |
| CAS号 | 13614-98-7 |
| 参考文献 | Padi and Kulkarni (2008) Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur.J.Pharmacol. 601 79. PMID: 18952075. Brundulaet al (2002) Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125 1297. PMID: 12023318. Tikkaet al (2001) Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J.Neurosci. 21 2580. PMID: 11306611. |