| 货号 | 4819/50 |
| 别名 | 11β,17β,21-Trihydroxy-6α-methyl-1,4-pr |
| 供应商 | Tocris |
| 生物活性 | Glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 374.47 |
| 分子式 | C22H30O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Xuet al (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J.Neurosci. 29 2022. PMID: 19228956. Leeet al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141. PMID: 18354017. |