| 货号 | 4245/50 |
| 别名 | 1-[(4-Chlorophenyl)phenylmethyl]4-[ |
| 供应商 | Tocris |
| 生物活性 | Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 463.87 |
| 分子式 | C25H27ClN2.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Lauet al (2011) Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 336 816. PMID: 21131266. Gohilet al (2010) Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 20 294. PMID: 20977989. Paradaet al (2001) The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102 937. PMID: 11182255. |