| 货号 | 1747/100 |
| 别名 | 4-[1-Hydroxy-2-[(1-methylethyl)amin |
| 供应商 | Tocris |
| 生物活性 | Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 247.72 |
| 分子式 | C11H17NO3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 51-30-9 |
| 参考文献 | Akimotoet al (2002) Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline. J.Smooth Muscle Res. 38 87. PMID: 12596888. Schmitt and Stork (2000) β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J.Biol.Chem. 275 25342. PMID: 10840035. Lottiet al (1982) Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2 169. PMID: 6292228. |