| 货号 | 3849/50 |
| 别名 | 1-Cyclopropyl-6-fluoro-1,4-dihydro- |
| 供应商 | Tocris |
| 生物活性 | Fluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 375.39 |
| 分子式 | C19H22FN3O4 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 112811-59-3 |
| 参考文献 | Desbordeset al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853. Fukudaet al (1998) Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917. PMID: 9687384. Takeiet al (1998) Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678. PMID: 9756776. |