| 货号 | 4751/1 |
| 供应商 | Tocris |
| 生物活性 | Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 796.97 |
| 分子式 | C39H60N10O8< |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | FSLLRY-NH2 (Modifications: Tyr-6 = C-terminal amide) |
| 参考文献 | Andohet al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91. PMID: 22761302. Chenet al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain. Neuroscience 193 440. PMID: 21763756. McLartyet al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264. PMID: 21730297. |