| 货号 | 2423/1 |
| 别名 | D-Ala-peptide T-amide |
| 供应商 | Tocris |
| 生物活性 | Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 856.89 |
| 分子式 | C35H56N10O15 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 106362-34-9 |
| 序列号 | ASTTTNYT (Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide) |
| 参考文献 | Polianovaet al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83. PMID: 16002156. Rosiet al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671. PMID: 15979806. Ruffet al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51. PMID: 15043212. |