| 货号 | 2685/50 |
| 别名 | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-me |
| 供应商 | Tocris |
| 生物活性 | Potentβ-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-,β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+(KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 406.47 |
| 分子式 | C24H26N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 72956-09-3 |
| 参考文献 | Kikutaet al (2006) Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529 47. PMID: 16325804. Ponickeet al (2002) Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71. PMID: 11907159. Ohlsteinet al (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 906189. |