| 货号 | 1761/50 |
| 别名 | 5,6,7-Trihydroxy-2-phenyl-(4H)-1-be |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 270.24 |
| 分子式 | C15H10O5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 491-67-8 |
| 参考文献 | Hsiehet al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5. PMID: 18039391. Nakahataet al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1. PMID: 12568909. Hsuet al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165. PMID: 11513834. Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090. PMID: 6807310. |