| 货号 | 2571/50 |
| 别名 | 2-[(2-Aminoethoxy)methyl]-4-(2-chlo |
| 供应商 | Tocris |
| 生物活性 | L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 567.05 |
| 分子式 | C20H25ClN2O5.C6H6O3S |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 111470-99-6 |
| 参考文献 | Tobaet al (2005) Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine. Hypertens.Res. 28 689. PMID: 16392774. Yoshidaet al (2003) Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 472 23. PMID: 12860469. Burgeset al (1987) Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 9 110. PMID: 2434785. |