| 货号 | 2404/50 |
| 别名 | trans-4-[[(2-Amino-3,5-dibromopheny |
| 供应商 | Tocris |
| 生物活性 | Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 414.57 |
| 分子式 | C13H18Br2N2O.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 23828-92-4 |
| 参考文献 | Weiser and Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol. Mol.Pharmacol. 62 433. PMID: 12181417. Gibbset al (1999) Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 48 86. PMID: 10202994. Gillissenet al (1997) Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 235. PMID: 9195551. |