| 货号 | 2513/50 |
| 别名 | 2-Amino-1,9-dihydro-9-[(2-hydroxyet |
| 供应商 | Tocris |
| 生物活性 | Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 225.21 |
| 分子式 | C8H11N5O3 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO |
| CAS号 | 59277-89-3 |
| 参考文献 | Hayashiet al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056. PMID: 16779868. Suzukiet al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157. PMID: 16797734. Elionet al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 745716. |