| 货号 | 2192/50 |
| 别名 | 4-(1H)-Quinazolinone |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50= 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 146.15 |
| 分子式 | C8H6N2O |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 491-36-1 |
| 参考文献 | Vereset al (2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 310 247. PMID: 14999056. Halmosiet al (2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 59 1497. PMID: 11353811. Banasiket al (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 267 1569. PMID: 1530940. |