| 货号 | 4433/1 |
| 别名 | N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5 |
| 供应商 | Tocris |
| 生物活性 | Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 550.54 |
| 分子式 | C27H25F3N8 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Mertinset al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099. PMID: 23437320. Chenet al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266. PMID: 17088537. Wu and Dinget al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3255. |