| 货号 | 21617-500ug |
| 描述 | β-Amyloid (1-40) peptide Aβ (1-40) is a 40-residue protein fragment of the C-terminal portion of the β-amyloid protein implicated in Alzheimer’s disease.1 Aβ (1-40) is more abundant, less neurotoxic, and does not form oligomers as easily as β-amyloid (1-42) peptide (Aβ (1-42) ; Item No. 20574).2,3 In rat cortical cultures, Aβ (1-40) (3 µM) prevented neuronal cell death by inhibiting fibril formation when administered concurrently with Aβ (1-42) (5, 10, and 20 µM).4 In the same study, Aβ (1-40) prevented neuronal damage when injected into rat entorhinal cortex with Aβ (1-42) (both at 400 µM). |
| 别名 | Aβ (1-40); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Selkoe, D.J. Alzheimer’s disease: A central role for amyloid. J. Neuropathol. Exp. Neurol. 53(5), 438-447 (1994). 2.Bitan, G.,Kirkitadze, M.D.,Lomakin, A., et al. Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc. Natl. Acad. Sci. USA 100(1), 330-335 (2003). 3.Murphy, M.P., and LeVinne, H., III. Alzheimer’s disease and the β-amyloid peptide. J. Alzheim. Dis. 19(1), 311 (2010). 4.Zou, K.,Kim, D.,Kakio, A., et al. Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brain. J. Neurochem. 87(3), 609-619 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 4329.9 |
| 分子式 | C194H295N53O58S |
| CAS号 | 131438-79-4 |
| 稳定性 | ≥ 2 years |
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