QX-314 (chloride)
货号：
18454-50mg 基本售价：
1386.0 元 规格：
50 mg
产品信息
概述| 货号 | 18454-50mg |
| 描述 | QX-314 is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application.1 When supplied in combination with 1 µM capsaicin (Item No. 92350), a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons.1 QX-314 elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics.1 At concentrations ranging from 10-70 mM, peripheral application of QX-314 dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.2 However, injection of 0.5-30 mM QX-314 in the lumbar intrathecal space produces neurotoxicity and death in mice.3 |
| 别名 | N-Ethyllidocaine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Binshtok, A.M.,Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449, 607-610 (2007).
2.Lim, T.K.Y.,MacLeod, B.A.,Ries, C.R., et al. The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo. Anesthesiology 107, 305-311 (2007).
3.Schwarz, S.K.W.,Cheung, H.M.C.,Ries, C.R., et al. Lumbar intrathecal administration of the quaternary lidocaine derivative, QX-314, produces irritation and death in mice. Anesthesiology 113, 438-444 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 298.9 |
| 分子式 | C16H27N2O • Cl |
| CAS号 | 1267096 |
| 稳定性 | ≥ 2 years |
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