| 货号 | 4619/50 |
| 别名 | 4-[Bis(2-Chloroethyl)amino]-L-pheny |
| 供应商 | Tocris |
| 生物活性 | DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >95 % |
| 计算分子量 | 305.2 |
| 分子式 | C13H18Cl2N2< |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 20 mM in 1eq. HCl |
| 参考文献 | Mougenotet al (2006) In vitro cytotoxic effect of melphalan and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 26 2197. PMID: 16821586. Bauer and Povirk (1997) Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25 1211. PMID: 9092631. Blumberget al (1965) An alkylating agent for multiple myeloma: melphalan. JAMA. 191 547. PMID: 14239026. Merck Index 125872. |