| 货号 | 11953-5mg |
| 描述 | SKF-86466 is a selective antagonist of α2-adrenoceptors that shows nanomolar Ki values for the three subtypes, α2A, α2B, and α2C.1,2 It is active in vivo, evoking antihypertensive effects in animal studies and clinical trials.3,2 SKF-86466 is used to study the role of α2-adrenoceptors in animals.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ruffolo, R.R., Jr.,Bondinell, W., and Hieble, J.P. α- and β-adrenoceptors: From the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J. Med. Chem. 38(19), 3681-3716 (1995). 2.Schafers, R.F.,Elliott, H.L.,Howie, C.A., et al. An evaluation of the α-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br. J. Clin. Pharmacol. 30(6), 884-888 (1990). 3.Roesler, J.M.,McCafferty, J.P.,DeMarinis, R.M., et al. Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J. Pharmacol. Exp. Ther. 236(1), 1-7 (1986). 4.Sáiz, J.,Pazos, A.,Del Olmo, E., et al. Yohimbine-induced alterations in α2-adrenoceptors in kidney regions of the spontaneously hypertensive rats: An autoradiographic analysis. Pharmacol. Rep. 60(3), 391-398 (2008). 5.Tanabe, M.,Hashimoto, M., and Ono, H. Imidazoline I1 receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson’s disease. Eur. J. Pharmacol. 589(1-3), 102-105 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 232.2 |
| 分子式 | C11H14ClN • HCl |
| CAS号 | 86129-54-6 |
| 稳定性 | ≥ 2 years |
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