| 货号 | 17966-100ug |
| 描述 | 33-cGAMP is a second messenger produced by bacteria but not by mammals. This hybrid cyclic AMP-GMP molecule is biosynthesized by specific dinucleotide cyclases and can regulate chemotaxis, colonization, and other cellular functions.1 Bacterial 33-cGAMP differs in its phosphodiester linkages from mammalian 23-cGAMP (Item No. 19887), which is produced by a nucleotidyltransferase known as cGAS.2 Bacteria-derived cyclic dinucleotides, including 33-cGAMP, trigger the expression of interferon genes in mammalian cells.2,3,4,5 |
| 别名 | Adenosine-Guanosine 3,3-cyclic monophosphate;c-GpAp;3,3-Cyclic GMP-AMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davies, B.W.,Bogard, R.W.,Young, T.S., et al. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell 149, 358-370 (2012). 2.Zhang, X.,Shi, H.,Wu, J., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51(2), 226-235 (2015). 3.Gao, P.,Ascano, M.,Zillinger, T., et al. Structure-function analysis of STING activation by c[G(2,5)pA(3,5)p] and targeting by antiviral DMXAA. Cell 154(4), 748-762 (2013). 4.Konno, H.,Konno, K., and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013). 5.Schaap, P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life 65(11), 897-903 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 674.4 |
| 分子式 | C20H24N10O13P2 |
| CAS号 | 849214-04-6 |
| 稳定性 | ≥ 2 years |
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