| 货号 | 1339/5 |
| 别名 | N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-ei |
| 供应商 | Tocris |
| 生物活性 | Endogenous cannabinoid and TRPV1 receptor agonist (Ki values are 89 and 371 nM at CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rTRPV1). Also blocks TNF-α-induced NF-κB activation via direct inhibition of IKK. Also available in water soluble emulsion (Cat. No. 1017). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 347.54 |
| 分子式 | C22H37NO2 |
| 可溶性/溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
| 参考文献 | Ryberget al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302. Sanchoet al (2003) Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429. PMID: 12527815. Rosset al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 132 631. PMID: 11159715. Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884. Devaneet al (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946. PMID: 1470919. |