| 货号 | 4988/1 |
| 别名 | 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-t |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α(IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 562.57 |
| 分子式 | C34H26O8 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Okadaet al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328. PMID: 23791076. Onoseet al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140. PMID: 23246504. Norikuraet al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974. PMID: 21630659. |