| 货号 | 5611/1 |
| 别名 | (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-F |
| 供应商 | Tocris |
| 生物活性 | Potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A (Cat. No. 2134). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 390.43 |
| 分子式 | C21H26O7 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Vardyet al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936. PMID: 25937170. Ansonoffet al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641. PMID: 16672569. |