| 货号 | 2147/50 |
| 别名 | N-[2-(Nitrooxy)ethyl]-3-pyridinecar |
| 供应商 | Tocris |
| 生物活性 | Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 211.18 |
| 分子式 | C8H9N3O4 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| CAS号 | 65141-46-0 |
| 参考文献 | Gommaet al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705. PMID: 11693460. Horinakaet al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200. PMID: 11483869. Shindoet al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985. PMID: 9692785. |