| 货号 | 1146/10 |
| 别名 | N-[N-[(Phenylmethoxy)carbonyl]-L-va |
| 供应商 | Tocris |
| 生物活性 | Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 382.45 |
| 分子式 | C22H26N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 88191-84-8 |
| 参考文献 | Aiet al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960. PMID: 17600513. Liet al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17. PMID: 9637399. Chenet al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188. PMID: 9374290. Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150. PMID: 1877091. |